Publications | Gale and Ira Drukier Institute for Children's Health

Gutzeit C, Grasset EK, Matthews DB, Maglione PJ, Britton GJ, Miller H, Magri G, Tomalin L, Stapylton M, Canales-Herrerias P et al.. 2025. Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses.. Sci Adv. 11(7):eado9455.

Brown JA, Bashir H, Zeng MY. 2025. Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.. Mucosal Immunol.

Ucar D, Thibodeau A, Mejias A, Nehar-Belaid D, Marches R, Xu Z, Eryilmaz G, Josefowicz S, Paust S, Pascual V et al.. 2025. Infants display reduced NK cell responses in RSV and increased inflammatory responses in SARS-CoV-2 infections.. Res Sq.

Lucotti S, Ogitani Y, Kenific CM, Geri J, Kim YHun, Gu J, Balaji U, Bojmar L, Shaashua L, Song Y et al.. 2025. Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2.. Cell.

Shailesh H, Noor S, Hayati L, Belavendra A, Van Panhuys N, Abou-Samra ABadi, Worgall S, Janahi I. 2024. Asthma and obesity increase inflammatory markers in children.. Front Allergy. 5:1536168.

Sloan EE, Kmetova K, NaveenKumar SK, Kluge L, Chong E, Hoy CK, Yalavarthi S, Sarosh C, Baisch J, Walters L et al.. 2024. Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome.. Clin Immunol. 261:109926.

Vaquero STejedor, Neuman H, Comerma L, Marcos-Fa X, Corral-Vazquez C, Uzzan M, Pybus M, Segura-Garzón D, Guerra J, Perruzza L et al.. 2024. Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease.. J Exp Med. 221(12)

Ravichandran S, Erra-Diaz F, Karakaslar OE, Marches R, Kenyon-Pesce L, Rossi R, Chaussabel D, Nehar-Belaid D, LaFon DC, Pascual V et al.. 2024. Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.. Nat Immunol. 25(2):316-329.

Kim Y, Maltseva N, Tesar C, Jedrzejczak R, Endres M, Ma H, Dugan HL, Stamper CT, Chang C, Li L et al.. 2024. Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies.. iScience. 27(2):108976.

Sanidad KZ, Rager SL, Carrow HC, Ananthanarayanan A, Callaghan R, Hart LR, Li T, Ravisankar P, Brown JA, Amir M et al.. 2024. Gut bacteria-derived serotonin promotes immune tolerance in early life.. Sci Immunol. 9(93):eadj4775.

Kim JK, Tierney BT, Overbey EG, Dantas E, Fuentealba M, Park J, S Narayanan A, Wu F, Najjar D, Chin CR et al.. 2024. Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight.. Nat Commun. 15(1):4954.

Menon S, Maurice D, Robinson LA, Milner J, Pascual V, Vinuesa CG, Kaicker S. 2024. Refractory Autoimmune Thrombocytopenia in an Infant with a De Novo TLR7 Gain-of-Function Variant.. J Clin Immunol. 45(1):27.

Overbey EG, Ryon K, Kim JK, Tierney BT, Klotz R, Ortiz V, Mullane S, Schmidt JC, MacKay M, Damle N et al.. 2024. Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).. Nat Commun. 15(1):4964.

Wan Z, Gu J, Balaji U, Bojmar L, Molina H, Heissel S, Pagano AE, Peralta C, Shaashua L, Ismailgeci D et al.. 2024. Optimization of ultracentrifugation-based method to enhance the purity and proteomic profiling depth of plasma-derived extracellular vesicles and particles.. J Extracell Biol. 3(7):e167.

Bojmar L, Kim HSang, Sugiura K, Heissel S, Lucotti S, Cioffi M, Johnson KEnnu, Cohen-Gould L, Zhang H, Molina H et al.. 2024. Protocol for cross-platform characterization of human and murine extracellular vesicles and particles.. STAR Protoc. 5(1):102754.

Overbey EG, Kim JK, Tierney BT, Park J, Houerbi N, Lucaci AG, Medina SGarcia, Damle N, Najjar D, Grigorev K et al.. 2024. The Space Omics and Medical Atlas (SOMA) and international astronaut biobank.. Nature.

Dror S, Lucotti S, Asao T, Li J, Wortzel I, Berger LShaashua, Matei I, Boudreau N, Zhang H, Jones D et al.. 2024. Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential.. Res Sq.

Deep D, Gudjonson H, Brown CC, Rose SA, Sharma R, Iza YAPaucar, Hong S, Hemmers S, Schizas M, Wang Z-M et al.. 2024. Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity.. J Exp Med. 221(11)

Nanaware PP, Khan ZN, Clement CC, Shetty M, Mota I, Seltzer ES, Dzieciatkowska M, Gamboni F, D'Alessandro A, Ng C et al.. 2024. Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load.. Cell Rep. 43(6):114311.

Balaji U, Rodriguez-Alcazar J, Balasubramanian P, Smitherman C, Baisch J, Pascual V, Gu J. 2024. Ragas: integration and enhanced visualization for single cell subcluster analysis.. Bioinformatics. 40(6)

Caielli S, Balasubramanian P, Rodriguez-Alcazar J, Balaji U, Robinson L, Wan Z, Baisch J, Smitherman C, Walters L, Sparagana P et al.. 2024. Type I IFN drives unconventional IL-1β secretion in lupus monocytes.. Immunity.

Wortzel I, Seo Y, Akano I, Shaashua L, Tobias GCardial, Hebert J, Kim K-A, Kim DA, Dror S, Liu Y et al.. 2024. Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression.. Nat Cancer.

Garagozlo K, Han J-Y, Worgall S, Thomas C, Wu A, Chang N, Gerber LM, Fiorino EK. 2024. Validation of diagnostic coding for children's interstitial lung disease (chILD).. Pediatr Pulmonol. 59(2):521-525.

Searles SC, Chen W-S, Yee JD, Lee P, Lee CK, Caron C, Neto F, Matei I, Lyden D, Bui JD. 2024. MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti-tumour immunity.. J Extracell Vesicles. 13(10):e12515.

Antonisamy B, Shailesh H, Hani Y, Ahmed LHayati M, Noor S, Ahmed SYahya, Alfaki M, Muhayimana A, Jacob SSunny, Balayya SKotegar et al.. 2023. Sphingolipids in Childhood Asthma and Obesity (SOAP Study): A Protocol of a Cross-Sectional Study.. Metabolites. 13(11)

Kusakabe T, Lin W-Y, Cheong J-G, Singh G, Ravishankar A, Yeung ST, Mesko M, DeCelie MBialt, Carriche G, Zhao Z et al.. 2023. Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19.. Nat Immunol. 24(11):1879-1889.

Cheong J-G, Ravishankar A, Sharma S, Parkhurst CN, Grassmann SA, Wingert CK, Laurent P, Ma S, Paddock L, Miranda IC et al.. 2023. Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.. Cell. 186(18):3882-3902.e24.

Caielli S, Balasubramanian P, Rodriguez-Alcazar J, Balaji U, Wan Z, Baisch J, Smitherman C, Walters L, Sparagana P, Nehar-Belaid D et al.. 2023. An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes.. bioRxiv.

Nouri N, Cao RGiacomelli, Bunsow E, Nehar-Belaid D, Marches R, Xu Z, Smith B, Heinonen S, Mertz S, Leber A et al.. 2023. Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations.. Nat Commun. 14(1):7976.

Kudo T, Zhao ML, Jeknić S, Kovary KM, LaGory EL, Covert MW, Teruel MN. 2023. Context-dependent regulation of lipid accumulation in adipocytes by a HIF1α-PPARγ feedback network.. Cell Syst. 14(12):1074-1086.e7.

Ravichandran S, Erra-Diaz F, Karakaslar OE, Marches R, Kenyon-Pesce L, Rossi R, Chaussabel D, Pascual V, Palucka K, Paust S et al.. 2023. Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.. medRxiv.

Cumpelik A, Cody E, Yu SMon-Wei, Grasset EK, Dominguez-Sola D, Cerutti A, Heeger PS. 2023. Cutting Edge: Neutrophil Complement Receptor Signaling Is Required for BAFF-Dependent Humoral Responses in Mice.. J Immunol. 210(1):19-23.

Gofshteyn J, Mansfield L, Spitznagle J, Balasubramanian P, Cardenas J, Miller T, Gu J, Wang X, Punaro M, Fuller J et al.. 2023. Juvenile dermatomyositis disease activity is associated with the expansion of blood B and T-cell memory subsets lacking follicular markers.. Arthritis Rheumatol.

Lengel HB, Mastrogiacomo B, Connolly JG, Tan KSee, Liu Y, Fick CN, Dunne EG, He D, Lankadasari MB, Satravada BAnusha et al.. 2023. Genomic mapping of metastatic organotropism in lung adenocarcinoma.. Cancer Cell. 41(5):970-985.e3.

Rager SL, Zeng MY. 2023. The Gut-Liver Axis in Pediatric Liver Health and Disease.. Microorganisms. 11(3)

Yu S, Zeng MY. 2023. Sex-biased gut dopamine signaling in multiple sclerosis.. Immunity. 56(12):2674-2676.

Liu S, Benito-Martin A, Vatter FAPelissie, Hanif SZ, Liu C, Bhardwaj P, Sethupathy P, Farghli AR, Piloco P, Paik P et al.. 2023. Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism.. bioRxiv.

Borowska MT, Boughter CT, Bunker JJ, Guthmiller JJ, Wilson PC, Roux B, Bendelac A, Adams EJ. 2023. Biochemical and biophysical characterization of natural polyreactivity in antibodies.. Cell Rep. 42(10):113190.

Kenari ANasiri, Bojmar L, Heissel S, Molina H, Lyden D, Hoshino A. 2023. Protocol for Plasma Extracellular Vesicle and Particle Isolation and Mass Spectrometry-Based Proteomic Identification.. Methods Mol Biol. 2628:291-300.

Borowska MT, Boughter CT, Bunker JJ, Guthmiller JJ, Wilson PC, Roux B, Bendelac A, Adams EJ. 2023. Biochemical and biophysical characterization of natural polyreactivity in antibodies.. Cell Rep. 42(10):113190.

Liu S, Benito-Martin A, Vatter FAPelissie, Hanif SZ, Liu C, Bhardwaj P, Sethupathy P, Farghli AR, Piloco P, Paik P et al.. 2023. Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism.. EMBO Rep. 24(12):e57339.

Caielli S, Wan Z, Pascual V. 2023. Systemic Lupus Erythematosus Pathogenesis: Interferon and Beyond.. Annu Rev Immunol.

Bolton MJ, Santos JJS, Arevalo CP, Griesman T, Watson M, Li SHang, Bates P, Ramage H, Wilson PC, Hensley SE. 2023. IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding.. Proc Natl Acad Sci U S A. 120(35):e2216521120.

Uryu K, Soplop N, Sheahan TP, Catanese M-T, Huynh C, Pena J, Boudreau N, Matei I, Kenific C, Hashimoto A et al.. 2023. Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach.. bioRxiv.

Changrob S, Halfmann PJ, Liu H, Torres JL, McGrath JJC, Ozorowski G, Li L, G Wilbanks D, Kuroda M, Maemura T et al.. 2023. Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct Omicron subvariants.. J Clin Invest.

Vieira MC, Palm A-KE, Stamper CT, Tepora ME, Nguyen KD, Pham TD, Boyd SD, Wilson PC, Cobey S. 2023. Germline-encoded specificities and the predictability of the B cell response.. PLoS Pathog. 19(8):e1011603.

Gregucci F, Spada S, Barcellos-Hoff MHelen, Bhardwaj N, Hak CChan Wah, Fiorentino A, Guha C, Guzman ML, Harrington K, Herrera FG et al.. 2023. Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference.. Oncoimmunology. 12(1):2222560.

Asao T, Tobias GCardial, Lucotti S, Jones DR, Matei I, Lyden D. 2023. Extracellular vesicles and particles as mediators of long-range communication in cancer: connecting biological function to clinical applications.. Extracell Vesicles Circ Nucl Acids. 4(3):461-485.

Worgall S. 2023. Environmental exposures: another effect on sphingolipids in asthma? Thorax. 78(3):222.

Shaw DG, Aguirre-Gamboa R, Vieira MC, Gona S, DiNardi N, Wang A, Dumaine A, Gelderloos-Arends J, Earley ZM, Meckel KR et al.. 2023. Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.. Nat Med. 29(6):1520-1529.

Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F et al.. 2023. Tumour extracellular vesicles and particles induce liver metabolic dysfunction.. Nature. 618(7964):374-382.

Savage A, Risquez C, Gomi K, Schreiner R, Borczuk AC, Worgall S, Silver RB. 2023. The mast cell exosome-fibroblast connection: A novel pro-fibrotic pathway.. Front Med (Lausanne). 10:1139397.

Li L, Sun J, Fu Y, Changrob S, McGrath JJC, Wilson PC. 2023. A hybrid single cell demultiplexing strategy that increases both cell recovery rate and calling accuracy.. bioRxiv.

Hu M, Kenific CM, Boudreau N, Lyden D. 2023. Tumor-derived nanoseeds condition the soil for metastatic organotropism.. Semin Cancer Biol. 93:70-82.

Dyke JP, Voskrebenzev A, Blatt LK, Vogel-Claussen J, Grimm R, Worgall S, Perlman JM, Kovanlikaya A. 2023. Assessment of lung ventilation of premature infants with bronchopulmonary dysplasia at 1.5 Tesla using phase-resolved functional lung magnetic resonance imaging.. Pediatr Radiol.

McGrath JJC, Wilson PC. 2023. Fate-mapping antibodies to study sinful immune dynamics.. Nat Immunol. 24(4):570-572.

Blavier L, Nakata R, Neviani P, Sharma K, Shimada H, Benedicto A, Matei I, Lyden D, DeClerck YA. 2023. The capture of extracellular vesicles endogenously released by xenotransplanted tumours induces an inflammatory reaction in the premetastatic niche.. J Extracell Vesicles. 12(5):e12326.

Bolton MJ, Arevalo CP, Griesman T, Li SHang, Bates P, Wilson PC, Hensley SE. 2022. IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding.. bioRxiv.

Dai J, Cimino PJ, Gouin KH, Grzelak CA, Barrett A, Lim AR, Long A, Weaver S, Saldin LT, Uzamere A et al.. 2022. Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain.. Nat Cancer. 3(1):25-42.

Choi J, Cho HYeon, Jeon J, Kim K-A, Han YDae, Ahn JBae, Wortzel I, Lyden D, Kim HSang. 2022. Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer.. Front Oncol. 12:1067210.

Zhang Z-B, Sinha J, Bahrami-Nejad Z, Teruel MN. 2022. The circadian clock mediates daily bursts of cell differentiation by periodically restricting cell-differentiation commitment.. Proc Natl Acad Sci U S A. 119(33):e2204470119.

Yu F, Courjaret R, Elmi A, Adap EAlcantara, Orie NN, Zghyer F, Hubrack S, Hayat S, Asaad N, Worgall S et al.. 2022. Chronic reduction of store operated Ca2+ entry is viable therapeutically but is associated with cardiovascular complications.. J Physiol. 600(22):4827-4848.

Sant AJ, Wilson PC. 2022. Learning from our differences.. Nat Immunol. 23(10):1403-1404.

Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W et al.. 2022. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.. Nat Commun. 13(1):6513.

Tholen S, Patel R, Agas A, Kovary KM, Rabiee A, Nicholls HT, Bielczyk-Maczyńska E, Yang W, Kraemer FB, Teruel MN. 2022. Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy.. Cell Rep. 39(13):111018.

Gourari I, Gomi R, Young M, Jordan G, Liongson M, Heras A, Gerber LM, Thomas C, Tsirilakis K, Ono J et al.. 2022. Asthma 17q21 polymorphism associates with decreased risk of COVID-19 in children.. Pediatr Pulmonol. 57(11):2855-2860.

Li L, Lan LYu-Ling, Huang L, Ye C, Andrade J, Wilson PC. 2022. Selecting Representative Samples From Complex Biological Datasets Using K-Medoids Clustering.. Front Genet. 13:954024.

Li Z, Low V, Luga V, Sun J, Earlie E, Parang B, Ganesh KShobana, Cho S, Endress J, Schild T et al.. 2022. Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.. Nat Commun. 13(1):6239.

Jin JC, Ananthanarayanan A, Brown JA, Rager SL, Bram Y, Sanidad KZ, Amir M, Baergen RN, Stuhlmann H, Schwartz RE et al.. 2022. SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy.. Pediatr Res. :1-8.

Grasset EK, Alenghat T. 2022. Good intentions gone wrong: The B cell block to epithelial repair.. Immunity. 55(12):2222-2224.

Strillacci A, Sansone P, Rajasekhar VK, Turkekul M, Boyko V, Meng F, Houck-Loomis B, Brown D, Berger MF, Hendrickson RC et al.. 2022. ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance.. NPJ Breast Cancer. 8(1):96.

McGrath JJC, Li L, Wilson PC. 2022. Memory B cell diversity: insights for optimized vaccine design.. Trends Immunol. 43(5):343-354.

Lucotti S, Kenific CM, Zhang H, Lyden D. 2022. Extracellular vesicles and particles impact the systemic landscape of cancer.. EMBO J. 41(18):e109288.

Li L, Changrob S, Fu Y, Stovicek O, Guthmiller JJ, McGrath JJC, Dugan HL, Stamper CT, Zheng N-Y, Huang M et al.. 2022. Librator: a platform for the optimized analysis, design, and expression of mutable influenza viral antigens.. Brief Bioinform. 23(2)

Brown GJ, Canete PF, Wang H, Medhavy A, Bones J, Roco JA, He Y, Qin Y, Cappello J, Ellyard JI et al.. 2022. TLR7 gain-of-function genetic variation causes human lupus.. Nature.

Huang Z, You X, Chen L, Du Y, Brodeur K, Jee H, Wang Q, Linder G, Darbousset R, Cunin P et al.. 2022. mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.. Nat Commun. 13(1):6915.

Wasserman E, Gomi R, Sharma A, Hong S, Bareja R, Gu J, Balaji U, Veerappan A, Kim BI, Wu W et al.. 2022. Human Rhinovirus Infection of the Respiratory Tract Affects Sphingolipid Synthesis.. Am J Respir Cell Mol Biol. 66(3):302-311.

Sanidad KZ, Amir M, Ananthanarayanan A, Singaraju A, Shiland NB, Hong HS, Kamada N, Inohara N, Nunez G, Zeng MY. 2022. Maternal gut microbiome-induced IgG regulates neonatal gut microbiome and immunity.. Sci Immunol. 7(72):eabh3816.

Brown JA, Sanidad KZ, Lucotti S, Lieber CM, Cox RM, Ananthanarayanan A, Basu S, Chen J, Shan M, Amir M et al.. 2022. Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection.. Gut Microbes. 14(1):2105609.

Lyden D, Ghajar CM, Correia ALuísa, Aguirre-Ghiso JA, Cai S, Rescigno M, Zhang P, Hu G, Fendt S-M, Boire A et al.. 2022. Metastasis.. Cancer Cell. 40(8):787-791.

Khan I, Gril B, Hoshino A, Yang HH, Lee MP, Difilippantonio S, Lyden DC, Steeg PS. 2022. Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems.. Clin Exp Metastasis.

Bahrami-Nejad Z, Zhang Z-B, Tholen S, Sharma S, Rabiee A, Zhao ML, Kraemer FB, Teruel MN. 2022. Early enforcement of cell identity by a functional component of the terminally differentiated state.. PLoS Biol. 20(12):e3001900.

Heras A, Gomi R, Young M, Chang CL, Wasserman E, Sharma A, Wu W, Gu J, Balaji U, White R et al.. 2022. Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate airway hyperreactivity.. Sci Rep. 12(1):19735.

Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC et al.. 2022. Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity.. Sci Adv. 8(40):eabn3777.

Ortiz R, Kluwe B, Lazarus S, Teruel MN, Joseph JJ. 2022. Cortisol and cardiometabolic disease: a target for advancing health equity.. Trends Endocrinol Metab. 33(11):786-797.

Arifuzzaman M, Won THyung, Li T-T, Yano H, Digumarthi S, Heras AF, Zhang W, Parkhurst CN, Kashyap S, Jin W-B et al.. 2022. Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation.. Nature. 611(7936):578-584.

Shor RE, Dai J, Lee S-Y, Pisarsky L, Matei I, Lucotti S, Lyden D, Bissell MJ, Ghajar CM. 2021. The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings.. Mol Oncol.

Wang G, Zhang H, Lyden D. 2021. Tumour-regulated anorexia preceding cachexia.. Nat Cell Biol. 23(2):111-113.

García-Silva S, Benito-Martin A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AAmor et al.. 2021. Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.. Nat Cancer. 2(12):1387-1405.

Grunberg N, Pevsner-Fischer M, Goshen-Lago T, Diment J, Stein Y, Lavon H, Mayer S, Levi-Galibov O, Friedman G, Ofir-Birin Y et al.. 2021. Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles.. Cancer Res. 81(7):1639-1653.

Vatter FAPelissie, Cioffi M, Hanna SJ, Castarede I, Caielli S, Pascual V, Matei I, Lyden D. 2021. Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses.. J Exp Med. 218(8)

Li L, Dugan HL, Stamper CT, Lan LYu-Ling, Asby NW, Knight M, Stovicek O, Zheng N-Y, Madariaga MLucia, Shanmugarajah K et al.. 2021. Improved integration of single-cell transcriptome and surface protein expression by LinQ-View.. Cell Rep Methods. 1(4):100056.

Altman MC, Rinchai D, Baldwin N, Toufiq M, Whalen E, Garand M, Kabeer BSyed Ahame, Alfaki M, Presnell SR, Khaenam P et al.. 2021. Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data.. Nat Commun. 12(1):4385.

Jones GD, Brandt WS, Shen R, Sanchez-Vega F, Tan KSee, Martin A, Zhou J, Berger M, Solit DB, Schultz N et al.. 2021. A Genomic-Pathologic Annotated Risk Model to Predict Recurrence in Early-Stage Lung Adenocarcinoma.. JAMA Surg. 156(2):e205601.

Kenific CM, Zhang H, Lyden D. 2021. An exosome pathway without an ESCRT.. Cell Res. 31(2):105-106.

Amir M, Zeng MY. 2021. Immune imprinting in utero.. Science. 373(6558):967-968.

Wan Z, Pascual V. 2021. Breaching self-tolerance by targeting the gatekeeper.. J Exp Med. 218(5)

Wasserman E, Worgall S. 2021. Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma.. Mol Cell Pediatr. 8(1):22.

Lawlor N, Nehar-Belaid D, Grassmann JDS, Stoeckius M, Smibert P, Stitzel ML, Pascual V, Banchereau J, Williams A, Ucar D. 2021. Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28.. Front Immunol. 12:636720.

Cullen SM, Hassan N, Smith-Raska M. 2021. Effects of non-inherited ancestral genotypes on offspring phenotypes.. Biol Reprod.

Bojmar L, Kim HSang, Tobias GC, Vatter FAPelissie, Lucotti S, Gyan KEnnu, Kenific CM, Wan Z, Kim K-A, Kim DA et al.. 2021. Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids.. STAR Protoc. 2(1):100225.

Teng F, Tachó-Piñot R, Sung B, Farber DL, Worgall S, Hammad H, Lambrecht BN, Hepworth MR, Sonnenberg GF. 2021. ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.. Cell Rep. 37(8):110051.

Tycko J, Adam VS, Crosariol M, Ohlstein J, Sanmiguel J, Tretiakova AP, Roy S, Worgall S, Wilson JM, Limberis MP. 2021. Adeno-Associated Virus Vector-Mediated Expression of Antirespiratory Syncytial Virus Antibody Prevents Infection in Mouse Airways.. Hum Gene Ther.

Ono JG, Worgall S. 2021. More Evidence for Inborn Dysregulation of Sphingolipid Metabolism in Children with Asthma? Am J Respir Crit Care Med. 203(7):792-793.

Caielli S, Cardenas J, de Jesus AAlmeida, Baisch J, Walters L, Blanck JPhilippe, Balasubramanian P, Stagnar C, Ohouo M, Hong S et al.. 2021. Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE.. Cell.

Winkler A, Sun W, De S, Jiao A, M Sharif N, Symanowicz PT, Athale S, Shin JH, Wang J, Jacobson BA et al.. 2021. The IRAK4 kinase inhibitor PF-06650833 blocks inflammation in preclinical models of rheumatologic disease and in humans enrolled in a randomized clinical trial.. Arthritis Rheumatol.

Notaras M, Lodhi A, Barrio-Alonso E, Foord C, Rodrick T, Jones D, Fang H, Greening D, Colak D. 2021. Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids.. Mol Psychiatry.

Jones GD, Caso R, Tan KSee, Mastrogiacomo B, Sanchez-Vega F, Liu Y, Connolly JG, Murciano-Goroff YR, Bott MJ, Adusumilli PS et al.. 2021. KRAS G12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma.. Clin Cancer Res. 27(9):2604-2612.

Guthmiller JJ, Han J, Utset HA, Li L, Lan LYu-Ling, Henry C, Stamper CT, McMahon M, O'Dell G, Fernández-Quintero ML et al.. 2021. Broadly neutralizing antibodies target a hemagglutinin anchor epitope.. Nature.

Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW et al.. 2021. Calcium signaling induces a partial EMT.. EMBO Rep. :e51872.

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