Exosome-Mediated Metastasis: Communication from a Distance.

TitleExosome-Mediated Metastasis: Communication from a Distance.
Publication TypeJournal Article
Year of Publication2019
AuthorsWortzel I, Dror S, Kenific CM, Lyden DC
JournalDev Cell
Date Published2019 05 06
KeywordsAnimals, Cell Communication, Disease Progression, Exosomes, Fibroblasts, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Tumor Microenvironment

Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes.

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Alternate JournalDev. Cell
PubMed ID31063754

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