Mechanisms of inflammation-driven bacterial dysbiosis in the gut.

TitleMechanisms of inflammation-driven bacterial dysbiosis in the gut.
Publication TypeJournal Article
Year of Publication2017
AuthorsZeng MY, Inohara N, Nuñez G
JournalMucosal Immunol
Date Published2017 01
KeywordsAnimals, Bacterial Infections, Cellular Microenvironment, Colorectal Neoplasms, Dysbiosis, Enterobacteriaceae, Food Hypersensitivity, Gastrointestinal Microbiome, Humans, Inflammation, Inflammatory Bowel Diseases, Virulence

The gut microbiota has diverse and essential roles in host metabolism, development of the immune system and as resistance to pathogen colonization. Perturbations of the gut microbiota, termed gut dysbiosis, are commonly observed in diseases involving inflammation in the gut, including inflammatory bowel disease, infection, colorectal cancer and food allergies. Importantly, the inflamed microenvironment in the gut is particularly conducive to blooms of Enterobacteriaceae, which acquire fitness benefits while other families of symbiotic bacteria succumb to environmental changes inflicted by inflammation. Here we summarize studies that examined factors in the inflamed gut that contribute to blooms of Enterobacterieaceae, and highlight potential approaches to restrict Enterobacterial blooms in treating diseases that are otherwise complicated by overgrowth of virulent Enterobacterial species in the gut.

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Alternate JournalMucosal Immunol
PubMed ID27554295
PubMed Central IDPMC5788567
Grant ListR01 DK091191 / DK / NIDDK NIH HHS / United States
T32 HL007517 / HL / NHLBI NIH HHS / United States
P30 DK034933 / DK / NIDDK NIH HHS / United States
R01 DK095782 / DK / NIDDK NIH HHS / United States
T32 DK094775 / DK / NIDDK NIH HHS / United States

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