Tumor-derived nanoseeds condition the soil for metastatic organotropism.

TitleTumor-derived nanoseeds condition the soil for metastatic organotropism.
Publication TypeJournal Article
Year of Publication2023
AuthorsHu M, Kenific CM, Boudreau N, Lyden D
JournalSemin Cancer Biol
Date Published2023 Aug
KeywordsCell Communication, Extracellular Vesicles, Humans, Neoplasms, Tumor Microenvironment

Primary tumors secrete a variety of factors to turn distant microenvironments into favorable and fertile 'soil' for subsequent metastases. Among these 'seeding' factors that initiate pre-metastatic niche (PMN) formation, tumor-derived extracellular vesicles (EVs) are of particular interest as tumor EVs can direct organotropism depending on their surface integrin profiles. In addition, EVs also contain versatile, bioactive cargo, which include proteins, metabolites, lipids, RNA, and DNA fragments. The cargo incorporated into EVs is collectively shed from cancer cells and cancer-associated stromal cells. Increased understanding of how tumor EVs promote PMN establishment and detection of EVs in bodily fluids highlight how tumor EVs could serve as potential diagnostic and prognostic biomarkers, as well as provide a therapeutic target for metastasis prevention. This review focuses on tumor-derived EVs and how they direct organotropism and subsequently modulate stromal and immune microenvironments at distal sites to facilitate PMN formation. We also outline the progress made thus far towards clinical applications of tumor EVs.

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Alternate JournalSemin Cancer Biol
PubMed ID37178822
PubMed Central IDPMC10362948
Grant ListR01 CA207983 / CA / NCI NIH HHS / United States
R35 CA232093 / CA / NCI NIH HHS / United States
TL1 TR002386 / TR / NCATS NIH HHS / United States
U54 CA163117 / CA / NCI NIH HHS / United States

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