| Title | Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Becker A, Thakur BKumar, Weiss JMitchell, Kim HSang, Peinado H, Lyden DC |
| Journal | Cancer Cell |
| Volume | 30 |
| Issue | 6 |
| Pagination | 836-848 |
| Date Published | 2016 Dec 12 |
| ISSN | 1878-3686 |
| Keywords | Biomarkers, Tumor, Cell Communication, Exosomes, Extracellular Vesicles, Humans, Neoplasm Metastasis, Neoplasms, Prognosis, Tumor Microenvironment |
| Abstract | Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development. |
| DOI | 10.1016/j.ccell.2016.10.009 |
| Custom 1 | |
| Alternate Journal | Cancer Cell |
| PubMed ID | 27960084 |
| PubMed Central ID | PMC5157696 |
| Grant List | R01 CA169416 / CA / NCI NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States U01 CA169538 / CA / NCI NIH HHS / United States |