Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.

TitleExtracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.
Publication TypeJournal Article
Year of Publication2016
AuthorsBecker A, Thakur BKumar, Weiss JMitchell, Kim HSang, Peinado H, Lyden DC
JournalCancer Cell
Date Published2016 Dec 12
KeywordsBiomarkers, Tumor, Cell Communication, Exosomes, Extracellular Vesicles, Humans, Neoplasm Metastasis, Neoplasms, Prognosis, Tumor Microenvironment

Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.

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Alternate JournalCancer Cell
PubMed ID27960084
PubMed Central IDPMC5157696
Grant ListR01 CA169416 / CA / NCI NIH HHS / United States
T32 GM007739 / GM / NIGMS NIH HHS / United States
U01 CA169538 / CA / NCI NIH HHS / United States

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