Breaching self-tolerance by targeting the gatekeeper.

TitleBreaching self-tolerance by targeting the gatekeeper.
Publication TypeJournal Article
Year of Publication2021
AuthorsWan Z, Pascual V
JournalJ Exp Med
Date Published2021 May 03

Loss-of-function mutations in DNaseL13, the enzyme that restricts the amount of microparticle-associated DNA, cause SLE in humans and mice. In this issue of JEM, Hartl et al. (2021. J. Exp. Med. uncover a reduction in plasma DNASE1L3 enzymatic activity due to the presence of autoantibodies in patients with nonfamilial SLE.

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Alternate JournalJ Exp Med
PubMed ID33847707

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