| Title | Breaching self-tolerance by targeting the gatekeeper. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Wan Z, Pascual V |
| Journal | J Exp Med |
| Volume | 218 |
| Issue | 5 |
| Date Published | 2021 May 03 |
| ISSN | 1540-9538 |
| Abstract | Loss-of-function mutations in DNaseL13, the enzyme that restricts the amount of microparticle-associated DNA, cause SLE in humans and mice. In this issue of JEM, Hartl et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201138) uncover a reduction in plasma DNASE1L3 enzymatic activity due to the presence of autoantibodies in patients with nonfamilial SLE. |
| DOI | 10.1084/jem.20210322 |
| Custom 1 | |
| Alternate Journal | J Exp Med |
| PubMed ID | 33847707 |