| Title | Cortisol and cardiometabolic disease: a target for advancing health equity. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Ortiz R, Kluwe B, Lazarus S, Teruel MN, Joseph JJ |
| Journal | Trends Endocrinol Metab |
| Volume | 33 |
| Issue | 11 |
| Pagination | 786-797 |
| Date Published | 2022 Nov |
| ISSN | 1879-3061 |
| Keywords | Cardiovascular Diseases, Health Equity, Humans, Hydrocortisone, Hypertension, Stress, Psychological |
| Abstract | Stress, in both intrinsic psychosocial and extrinsic physical environmental forms, can impact the development of, and outcomes in, cardiovascular disease (CVD) through allostatic load. Cortisol is a core hormonal mediator of allostatic load produced in response to various stresses. Alterations in morning serum cortisol and daily diurnal cortisol have been associated with adiposity, dyslipidemia, incident diabetes, and CVDs such as hypertension. The review examines the role of cortisol as a key mechanistic link between stress physiology and cardiometabolic disease. Importantly, we discuss the role of targeting cortisol through pharmacological, behavioral, and environmental interventions to advance health equity in cardiometabolic disease. |
| DOI | 10.1016/j.tem.2022.08.002 |
| Custom 1 | |
| Alternate Journal | Trends Endocrinol Metab |
| PubMed ID | 36266164 |
| PubMed Central ID | PMC9676046 |
| Grant List | K23 DK117041 / DK / NIDDK NIH HHS / United States R01 DK132403 / DK / NIDDK NIH HHS / United States R56 DK131432 / DK / NIDDK NIH HHS / United States |