Cortisol and cardiometabolic disease: a target for advancing health equity.

TitleCortisol and cardiometabolic disease: a target for advancing health equity.
Publication TypeJournal Article
Year of Publication2022
AuthorsOrtiz R, Kluwe B, Lazarus S, Teruel MN, Joseph JJ
JournalTrends Endocrinol Metab
Date Published2022 Nov
KeywordsCardiovascular Diseases, Health Equity, Humans, Hydrocortisone, Hypertension, Stress, Psychological

Stress, in both intrinsic psychosocial and extrinsic physical environmental forms, can impact the development of, and outcomes in, cardiovascular disease (CVD) through allostatic load. Cortisol is a core hormonal mediator of allostatic load produced in response to various stresses. Alterations in morning serum cortisol and daily diurnal cortisol have been associated with adiposity, dyslipidemia, incident diabetes, and CVDs such as hypertension. The review examines the role of cortisol as a key mechanistic link between stress physiology and cardiometabolic disease. Importantly, we discuss the role of targeting cortisol through pharmacological, behavioral, and environmental interventions to advance health equity in cardiometabolic disease.

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Alternate JournalTrends Endocrinol Metab
PubMed ID36266164
PubMed Central IDPMC9676046
Grant ListK23 DK117041 / DK / NIDDK NIH HHS / United States
R01 DK132403 / DK / NIDDK NIH HHS / United States
R56 DK131432 / DK / NIDDK NIH HHS / United States

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