The Gut-Liver Axis in Pediatric Liver Health and Disease.

TitleThe Gut-Liver Axis in Pediatric Liver Health and Disease.
Publication TypeJournal Article
Year of Publication2023
AuthorsRager SL, Zeng MY
Date Published2023 Feb 27

There has been growing interest in the complex host-microbe interactions within the human gut and the role these interactions play in systemic health and disease. As an essential metabolic organ, the liver is intimately coupled to the intestinal microbial environment via the portal venous system. Our understanding of the gut-liver axis comes almost exclusively from studies of adults; the gut-liver axis in children, who have unique physiology and differing gut microbial communities, remains poorly understood. Here, we provide a comprehensive overview of common pediatric hepatobiliary conditions and recent studies exploring the contributions of the gut microbiota to these conditions or changes of the gut microbiota due to these conditions. We examine the current literature regarding the microbial alterations that take place in biliary atresia, pediatric non-alcoholic fatty liver disease, Wilson's disease, cystic fibrosis, inflammatory bowel disease, and viral hepatitis. Finally, we propose potential therapeutic approaches involving modulation of the gut microbiota and the gut-liver axis to mitigate the progression of pediatric liver disease.

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Alternate JournalMicroorganisms
PubMed ID36985171
PubMed Central IDPMC10051507
Grant ListR01 HL169989 / HL / NHLBI NIH HHS / United States
R01 HD110118 / HD / NICHD NIH HHS / United States
K01DK114376 / DK / NIDDK NIH HHS / United States
R21CA270998 / CA / NCI NIH HHS / United States
K01 DK114376 / DK / NIDDK NIH HHS / United States

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