Memory B cell diversity: insights for optimized vaccine design.

TitleMemory B cell diversity: insights for optimized vaccine design.
Publication TypeJournal Article
Year of Publication2022
AuthorsMcGrath JJC, Li L, Wilson PC
JournalTrends Immunol
Date Published2022 May
KeywordsAnimals, Antibodies, Viral, B-Lymphocytes, COVID-19, Humans, Immunologic Memory, Mammals, Memory B Cells, SARS-CoV-2, Vaccination, Vaccines

The overarching logos of mammalian memory B cells (MBCs) is to cache the potential for enhanced antibody production upon secondary exposure to cognate antigenic determinants. However, substantial phenotypic diversity has been identified across MBCs, hinting at the existence of unique origins or subfunctions within this compartment. Herein, we discuss recent advancements in human circulatory MBC subphenotyping as driven by high-throughput cell surface marker analysis and other approaches, as well as speculated and substantiated subfunctions. With this in mind, we hypothesize that the relative induction of specific circulatory MBC subsets might be used as a biomarker for optimally durable vaccines and inform vaccination strategies to subvert antigenic imprinting in the context of highly mutable pathogens such as influenza virus or SARS-CoV-2.

Custom 1

Alternate JournalTrends Immunol
PubMed ID35393268
PubMed Central IDPMC8977948

Weill Cornell Medicine Gale and Ira Drukier Institute for Children's Health 413 E. 69th Street New York, NY 10021