Pre-Metastatic Niche Formation Has Taken Its TOLL.

TitlePre-Metastatic Niche Formation Has Taken Its TOLL.
Publication TypeJournal Article
Year of Publication2016
AuthorsKenific CM, Nogués L, Lyden DC
JournalCancer Cell
Date Published2016 08 08
KeywordsEpithelial Cells, Humans, Lung, Neoplasm Metastasis, Neoplasms, RNA, Neoplasm, Tumor Microenvironment

Pre-Metastatic Niches (PMNs) result from communications between primary tumors and the microenvironment of future distant metastasis via tumor-derived factors. In this issue of Cancer Cell, Liu et al. show that TLR3 activation in lung epithelial cells by tumor exosomal RNAs triggers neutrophil recruitment, which contributes to PMN formation and metastasis.

Custom 1

Alternate JournalCancer Cell
PubMed ID27505667

Weill Cornell Medicine Gale and Ira Drukier Institute for Children's Health 413 E. 69th Street New York, NY 10021