Gale and Ira Drukier Institute for Children's Health

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Tumor Extracellular Vesicles Impede Interferon Alert Responses.

TitleTumor Extracellular Vesicles Impede Interferon Alert Responses.
Publication TypeJournal Article
Year of Publication2019
AuthorsKenific CM, Wang G, Lyden D
JournalCancer Cell
Volume35
Issue1
Pagination3-5
Date Published2019 Jan 14
ISSN1878-3686
Abstract

Tumor-derived extracellular vesicles promote metastasis by inducing functional changes in cells at pre-metastatic sites conducive for tumor cell colonization. In this issue of Cancer Cell, Ortiz and colleagues show that type I interferon regulates extracellular vesicle uptake and that modulating this pathway holds promise for treating metastasis.

DOI10.1016/j.ccell.2018.12.006
Alternate JournalCancer Cell
PubMed ID30645974