Extracellular vesicles and particles impact the systemic landscape of cancer.

TitleExtracellular vesicles and particles impact the systemic landscape of cancer.
Publication TypeJournal Article
Year of Publication2022
AuthorsLucotti S, Kenific CM, Zhang H, Lyden D
JournalEMBO J
Date Published2022 Sep 15
KeywordsCell Communication, Extracellular Vesicles, Humans, Immunotherapy, Neoplasms, Tumor Microenvironment

Intercellular cross talk between cancer cells and stromal and immune cells is essential for tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a heterogeneous class of secreted messengers that carry bioactive molecules and that have been shown to be crucial for this cell-cell communication. Here, we highlight the multifaceted roles of EVPs in cancer. Functionally, transfer of EVP cargo between cells influences tumor cell growth and invasion, alters immune cell composition and function, and contributes to stromal cell activation. These EVP-mediated changes impact local tumor progression, foster cultivation of pre-metastatic niches at distant organ-specific sites, and mediate systemic effects of cancer. Furthermore, we discuss how exploiting the highly selective enrichment of molecules within EVPs has profound implications for advancing diagnostic and prognostic biomarker development and for improving therapy delivery in cancer patients. Altogether, these investigations into the role of EVPs in cancer have led to discoveries that hold great promise for improving cancer patient care and outcome.

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Alternate JournalEMBO J
PubMed ID36052513
PubMed Central IDPMC9475536
Grant ListR01 CA218513 / CA / NCI NIH HHS / United States

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