| Title | Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Matei IR, Kim HSang, Lyden DC |
| Journal | Cell |
| Volume | 170 |
| Issue | 2 |
| Pagination | 223-225 |
| Date Published | 2017 07 13 |
| ISSN | 1097-4172 |
| Keywords | Exosomes, Humans, Neoplasms, RNA |
| Abstract | Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis. |
| DOI | 10.1016/j.cell.2017.06.047 |
| Custom 1 | |
| Alternate Journal | Cell |
| PubMed ID | 28708994 |