Title | Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Vatter FAPelissie, Cioffi M, Hanna SJ, Castarede I, Caielli S, Pascual V, Matei I, Lyden D |
Journal | J Exp Med |
Volume | 218 |
Issue | 8 |
Date Published | 2021 08 02 |
ISSN | 1540-9538 |
Keywords | Adaptive Immunity, Animals, Cell Communication, Cell-Derived Microparticles, Extracellular Vesicles, Humans, Immunity, Innate, Immunotherapy |
Abstract | Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ physiology in both health and disease. Under normal physiological conditions, immune cell-derived EVPs participate in immune responses by regulating innate and adaptive immune responses. EVPs play a major role in antigen presentation and immune activation. On the other hand, immune cell-derived EVPs exert immunosuppressive and regulatory effects. Consequently, EVPs may contribute to pathological conditions, such as autoimmune and inflammatory diseases, graft rejection, and cancer progression and metastasis. Here, we provide an overview of the role of EVPs in immune homeostasis and pathophysiology, with a particular focus on their contribution to innate and adaptive immunity and their potential use for immunotherapies. |
DOI | 10.1084/jem.20202579 |
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Alternate Journal | J Exp Med |
PubMed ID | 34180950 |
PubMed Central ID | PMC8241538 |
Grant List | U54 CA163117 / CA / NCI NIH HHS / United States R01 CA218513 / CA / NCI NIH HHS / United States U19 AI144301 / AI / NIAID NIH HHS / United States K00 CA212451 / CA / NCI NIH HHS / United States R01 CA207983 / CA / NCI NIH HHS / United States P2SKP3 174785 / SNSF_ / Swiss National Science Foundation / Switzerland U54 CA163120 / CA / NCI NIH HHS / United States U01 CA224175 / CA / NCI NIH HHS / United States U01 CA210240 / CA / NCI NIH HHS / United States NCI CA224175 / NH / NIH HHS / United States R35 CA232093 / CA / NCI NIH HHS / United States |