Maternal Microbiome and Infections in Pregnancy.

TitleMaternal Microbiome and Infections in Pregnancy.
Publication TypeJournal Article
Year of Publication2020
AuthorsAmir M, Brown JA, Rager SL, Sanidad KZ, Ananthanarayanan A, Zeng MY
Date Published2020 Dec 15

Pregnancy induces unique changes in maternal immune responses and metabolism. Drastic physiologic adaptations, in an intricately coordinated fashion, allow the maternal body to support the healthy growth of the fetus. The gut microbiome plays a central role in the regulation of the immune system, metabolism, and resistance to infections. Studies have reported changes in the maternal microbiome in the gut, vagina, and oral cavity during pregnancy; it remains unclear whether/how these changes might be related to maternal immune responses, metabolism, and susceptibility to infections during pregnancy. Our understanding of the concerted adaption of these different aspects of the human physiology to promote a successful pregnant remains limited. Here, we provide a comprehensive documentation and discussion of changes in the maternal microbiome in the gut, oral cavity, and vagina during pregnancy, metabolic changes and complications in the mother and newborn that may be, in part, driven by maternal gut dysbiosis, and, lastly, common infections in pregnancy. This review aims to shed light on how dysregulation of the maternal microbiome may underlie obstetrical metabolic complications and infections.

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Alternate JournalMicroorganisms
PubMed ID33333813
PubMed Central IDPMC7765218
Grant ListDK114376 / NH / NIH HHS / United States

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