Effects of non-inherited ancestral genotypes on offspring phenotypes.

TitleEffects of non-inherited ancestral genotypes on offspring phenotypes.
Publication TypeJournal Article
Year of Publication2021
AuthorsCullen SM, Hassan N, Smith-Raska M
JournalBiol Reprod
Date Published2021 Jun 22

It is well established that environmental exposures can modify the profile of heritable factors in an individual's germ cells, ultimately affecting the inheritance of phenotypes in descendants. Similar to exposures, an ancestor's genotype can also affect the inheritance of phenotypes across generations, sometimes in offspring who do not inherit the genetic aberration. This can occur via a variety of prenatal, in utero, or postnatal mechanisms. In this review, we discuss the evidence for this process in mammals, with a focus on examples that are potentially mediated through the germline, while also considering alternate routes of inheritance. Non-inherited ancestral genotypes may influence descendant's disease risk to a much greater extent than currently appreciated, and focused evaluation of this phenomenon may reveal novel mechanisms of inheritance.

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Alternate JournalBiol Reprod
PubMed ID34159361

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