Sex-biased gut dopamine signaling in multiple sclerosis.

TitleSex-biased gut dopamine signaling in multiple sclerosis.
Publication TypeJournal Article
Year of Publication2023
AuthorsYu S, Zeng MY
Date Published2023 Dec 12
KeywordsAnimals, Dopamine, Female, Inflammation, Mice, Multiple Sclerosis, Sexism

Multiple sclerosis shows a strong sex bias, with unclear mechanisms. In this issue of Immunity, Peng et al. elucidate a female-biased increase in intestinal dopamine signaling that diminishes protective Lactobacillus and exacerbates inflammation in a mouse model of multiple sclerosis.

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Alternate JournalImmunity
PubMed ID38091947
PubMed Central IDPMC10908588
Grant ListK01 DK114376 / DK / NIDDK NIH HHS / United States
R01 HD110118 / HD / NICHD NIH HHS / United States
R01 HL169989 / HL / NHLBI NIH HHS / United States
R21 CA270998 / CA / NCI NIH HHS / United States

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