Title | Sex-biased gut dopamine signaling in multiple sclerosis. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Yu S, Zeng MY |
Journal | Immunity |
Volume | 56 |
Issue | 12 |
Pagination | 2674-2676 |
Date Published | 2023 Dec 12 |
ISSN | 1097-4180 |
Keywords | Animals, Dopamine, Female, Inflammation, Mice, Multiple Sclerosis, Sexism |
Abstract | Multiple sclerosis shows a strong sex bias, with unclear mechanisms. In this issue of Immunity, Peng et al. elucidate a female-biased increase in intestinal dopamine signaling that diminishes protective Lactobacillus and exacerbates inflammation in a mouse model of multiple sclerosis. |
DOI | 10.1016/j.immuni.2023.11.016 |
Custom 1 | |
Alternate Journal | Immunity |
PubMed ID | 38091947 |
PubMed Central ID | PMC10908588 |
Grant List | K01 DK114376 / DK / NIDDK NIH HHS / United States R01 HD110118 / HD / NICHD NIH HHS / United States R01 HL169989 / HL / NHLBI NIH HHS / United States R21 CA270998 / CA / NCI NIH HHS / United States |