Constitutive resistance to viral infection in human CD141 dendritic cells.

TitleConstitutive resistance to viral infection in human CD141 dendritic cells.
Publication TypeJournal Article
Year of Publication2017
AuthorsSilvin A, Yu CI, Lahaye X, Imperatore F, Brault J-B, Cardinaud S, Becker C, Kwan W-H, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, GarcĂ­a-Sastre A, Goud B, Dalod M, Moris A, Merad M, A Palucka K, Manel N
JournalSci Immunol
Volume2
Issue13
Date Published2017 Jul 07
ISSN2470-9468
Abstract

Dendritic cells (DCs) are critical for the launching of protective T cell immunity in response to viral infection. Viruses can directly infect DCs, thereby compromising their viability and suppressing their ability to activate immune responses. How DC function is maintained in light of this paradox is not understood. By analyzing the susceptibility of primary human DC subsets to viral infections, we report that CD141 DCs have an innate resistance to infection by a broad range of enveloped viruses, including HIV and influenza virus. In contrast, CD1c DCs are susceptible to infection, which enables viral antigen production but impairs their immune functions and survival. The ability of CD141 DCs to resist infection is conferred by RAB15, a vesicle-trafficking protein constitutively expressed in this DC subset. We show that CD141 DCs rely on viral antigens produced in bystander cells to launch cross-presentation-driven T cell responses. By dissociating viral infection from antigen presentation, this mechanism protects the functional capacity of DCs to launch adaptive immunity against viral infection.

DOI10.1126/sciimmunol.aai8071
Custom 1

https://www.ncbi.nlm.nih.gov/pubmed/28783704?dopt=Abstract

Alternate JournalSci Immunol
PubMed ID28783704
PubMed Central IDPMC5749640
Grant ListHHSN272201400008C / AI / NIAID NIH HHS / United States
R01 CA154947 / CA / NCI NIH HHS / United States
U19 AI117873 / AI / NIAID NIH HHS / United States
U19 AI118610 / AI / NIAID NIH HHS / United States
U19 AI057234 / AI / NIAID NIH HHS / United States
U01 AI095611 / AI / NIAID NIH HHS / United States
R01 DA033773 / DA / NIDA NIH HHS / United States
R01 CA173861 / CA / NCI NIH HHS / United States
U19 AI089987 / AI / NIAID NIH HHS / United States

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