| Title | Pre-metastatic niches: organ-specific homes for metastases. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RNatasha, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden DC |
| Journal | Nat Rev Cancer |
| Volume | 17 |
| Issue | 5 |
| Pagination | 302-317 |
| Date Published | 2017 05 |
| ISSN | 1474-1768 |
| Keywords | Animals, Humans, Neoplasm Metastasis, Neoplasms, Neoplastic Cells, Circulating, Tumor Microenvironment |
| Abstract | It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche. |
| DOI | 10.1038/nrc.2017.6 |
| Custom 1 | |
| Alternate Journal | Nat. Rev. Cancer |
| PubMed ID | 28303905 |
| Grant List | U54 CA193461 / CA / NCI NIH HHS / United States U01 CA169538 / CA / NCI NIH HHS / United States |