| Title | The interplay between host immune cells and gut microbiota in chronic inflammatory diseases. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Kim D, Zeng MY, Nunez G |
| Journal | Exp Mol Med |
| Volume | 49 |
| Issue | 5 |
| Pagination | e339 |
| Date Published | 2017 05 26 |
| ISSN | 2092-6413 |
| Keywords | Animals, Arthritis, Rheumatoid, Asthma, Bacteria, Dysbiosis, Gastrointestinal Microbiome, Humans, Inflammation, Inflammatory Bowel Diseases, Intestinal Mucosa, Mice, Multiple Sclerosis |
| Abstract | Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between the gut microbiota and host cells, resulting in dysregulation of inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, multiple sclerosis, allergic asthma and rheumatoid arthritis. In this review, we provide an overview of how gut bacteria modulates host metabolic and immune functions, summarize studies that examined the roles of gut dysbiosis in chronic inflammatory diseases, and finally discuss measures to correct gut dysbiosis as potential therapeutics for chronic inflammatory diseases. |
| DOI | 10.1038/emm.2017.24 |
| Custom 1 | |
| Alternate Journal | Exp. Mol. Med. |
| PubMed ID | 28546562 |
| PubMed Central ID | PMC5454439 |
| Grant List | R01 DK061707 / DK / NIDDK NIH HHS / United States R01 DK091191 / DK / NIDDK NIH HHS / United States T32 HL007517 / HL / NHLBI NIH HHS / United States |