| Title | Pre-Metastatic Niche Formation Has Taken Its TOLL. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Kenific CM, Nogués L, Lyden DC |
| Journal | Cancer Cell |
| Volume | 30 |
| Issue | 2 |
| Pagination | 189-191 |
| Date Published | 2016 08 08 |
| ISSN | 1878-3686 |
| Keywords | Epithelial Cells, Humans, Lung, Neoplasm Metastasis, Neoplasms, RNA, Neoplasm, Tumor Microenvironment |
| Abstract | Pre-Metastatic Niches (PMNs) result from communications between primary tumors and the microenvironment of future distant metastasis via tumor-derived factors. In this issue of Cancer Cell, Liu et al. show that TLR3 activation in lung epithelial cells by tumor exosomal RNAs triggers neutrophil recruitment, which contributes to PMN formation and metastasis. |
| DOI | 10.1016/j.ccell.2016.07.012 |
| Custom 1 | |
| Alternate Journal | Cancer Cell |
| PubMed ID | 27505667 |