The Drukier Prize honors an early-career pediatrician whose research has made important contributions toward improving the health of children and adolescents. Dr. Su, chief of the Human Immunological Diseases Section at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is being recognized for her innovative research into rare pediatric immunodeficiency diseases and translating findings into potential treatments for these patients. This work also extends to more common diseases such as allergies and viral infections.
“Dr. Su is a talented clinician-scientist whose discoveries have furthered our understanding of the genetic causes of rare pediatric immune diseases,” said Dr. Augustine M.K. Choi, the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine. “Her innovative research using cutting-edge approaches and efforts to translate her work into new treatments has offered hope to countless children affected by these disorders and their families. For her commitment to children’s health and tireless work to advance the field of pediatric research, we are pleased to honor Dr. Su with this year’s Gale and Ira Drukier Prize in Children’s Health Research.”
“We are thrilled to be recognizing Dr. Su with this award,” said Dr. Gale Drukier and Weill Cornell Medicine Overseer Ira Drukier, who together in 2014 established the prize. “Dr. Su’s dedication to bettering the lives of young patients through her groundbreaking pediatric research into DOCK8 immunodeficiency syndrome and other rare immune disorders is exceptional. We are proud to have the opportunity to showcase the inspiring physicians and scientists making a true difference in children’s health, offering a bright future for the next generation.”
“Dr. Su’s research illustrates the value of understanding the basis of rare hereditary immune disorders,” said Dr. Virginia Pascual, the Drukier Director of the Gale and Ira Drukier Institute for Children’s Health. “Not only has her work helped to guide treatment for children with these diseases, but she has also advanced the field of immunology through her fundamental insights into how the human body protects itself from infection. Her research has the potential to help children worldwide and the Drukier Institute is pleased to honor Dr. Su for her vital contributions to pediatric research.”
Dr. Su’s research brings together clinical information with technological developments in genomics, biochemistry and molecular biology—such as sequencing all the protein-coding regions of the human genome—to identify gene mutations associated with diseases that affect the immune system. The findings may lead to improved diagnosis and better treatments.
Dr. Su’s work has provided critical insights into DOCK8 immunodeficiency syndrome, a rare immune system disease that is difficult to diagnose because it masquerades as more common conditions, such as respiratory infections, middle ear infections, eczema, food allergies and skin infections. Children with DOCK8 immunodeficiency syndrome, however, reach a point at which infections of the skin and respiratory system worsen over time, and they are at increased risk for some forms of cancer. In 2014, Dr. Su and her colleagues showed that when the DOCK8 protein is missing, as occurs in these patients, white blood cells that travel to the skin and normally fight off viral infections there catastrophically die, impairing immunity within the skin. Some children with DOCK8 immunodeficiency syndrome have been successfully treated with bone marrow transplants, and Dr. Su is collaborating with other teams at NIH to determine which type of transplant—from matched siblings, matched unrelated donors, or half-matched donors, such as mothers or fathers or half-matched siblings—offer the best treatment.
Recently, Dr. Su and her colleagues identified a rare mutation in the gene that produces a protein called MDA5, which plays an important role in fighting viral infections. The faulty MDA5 protein results in a markedly increased susceptibility to infection by human rhinoviruses, the main causes of the common cold. For most people, rhinovirus infections lead to minor illness, but for people with severe asthma, chronic obstructive pulmonary disease and other health problems, rhinoviruses can cause serious complications. Insights from Dr. Su’s research may lead to new strategies for treating patients with severe rhinovirus complications and inadequate MDA5 responses.
The Gale and Ira Drukier Prize in Children’s Health Research was established in December 2014 as part of a $25 million gift to Weill Cornell Medicine. The gift also created the Gale and Ira Drukier Institute for Children’s Health – a premier, cross-disciplinary institute dedicated to understanding the underlying causes of diseases that are devastating to children. As part of its mission, the institute awards the prize, which carries an unrestricted honorarium, annually to recognize the innovative work done by young investigators in pediatric research.
Dr. Su received a Bachelor of Arts degree from Brown University in 1990. She went on to earn a medical degree and a doctorate in pathobiology, both from Brown, in 1998. After completing an internship and residency in pediatrics at St. Louis Children’s Hospital, she joined NIAID in 2002 as a clinical fellow in allergy and immunology. After completing a research fellowship in NIAID’s Laboratory of Immunology in 2007, she was appointed as a clinical investigator and chief of the Human Immunological Diseases Unit in the Laboratory of Host Defenses at NIAID. In 2016, she was named senior investigator and chief of Laboratory of Host Defenses at NIAID. In 2017, Dr. Su became senior investigator and chief of the Human Immunological Diseases Section in the Laboratory of Clinical Immunology and Microbiology at NIAID.
Dr. Su has received several awards and honors, including the NIH Director’s Award in 2010 and NIH Merit Awards in 2015 and 2018, and the Society for Pediatric Research E. Mead Johnson Award in 2018.