Work in the Pediatric Pulmonary Research Laboratory is focused on how lungs of children with common chronic diseases respond to viral and bacterial infections. A main focus of the research efforts is on Pseudomonas aeruginosa in cystic fibrosis lung disease and common respiratory viral infections in asthma. Part of this work involves the development and assessment of novel genetic vaccines. A recent focus is on the role of sphingolipids in the development of childhood asthma and its responses to viral infections that most often trigger asthma flares in children. In addition, the laboratory is engaged in collaborative studies on mast cells and their products for lung disease of premature infants and the interaction of lung microbiota with infections in asthma and cystic fibrosis.